Profhilo Explained: The Ultimate Guide to Skin Rejuvenation in London

Table of Contents

• What is Profhilo?
• How Does Profhilo Work?
• Why is Collagen Important?
• Why is Elastin Important?
• How Does Profhilo Stimulate Collagen and Elastin Production?
• How Deep is Profhilo Injected?
• Where Topographically on the Face is Profhilo Injected?
• When Does Profhilo Start Working and How Long Does It Last?
• Why are Two Sets of Injections Administered with a Four-Week Interval?
• What is the Evidence That Profhilo Works?

What is Profhilo?

Profhilo is the trade name for an injectable gel that contains a high concentration of hyaluronic acid. Used in aesthetic medicine, it aims to give the skin a firmer, more youthful appearance.

How Does Profhilo Work?

Profhilo is injected directly into the target treatment area and has four main effects:

1. Hyaluronic acid instantly provides volume to the skin.
2. Hyaluronic acid binds to water molecules, hydrating and adding further volume to the skin.
3. Hyaluronic acid stimulates collagen production in the skin.
4. Hyaluronic acid stimulates elastin production in the skin.

https://londonskinclinic.london/profhilo/

Why is Collagen Important?

Collagen is a key structural protein in the body, with types I and III being most significant in the skin. Type I provides a scaffold for the skin, giving it tensile strength and preventing stretching and tearing, while also binding to water molecules to provide hydration. Type III collagen is more pliable, crucial for wound healing, as it forms a temporary matrix to support tissue regeneration when the skin is injured. As we age, collagen production decreases.

Why is Elastin Important?

Elastin is essential for skin elasticity and resilience, allowing it to stretch and bounce back. It helps maintain firmness, preventing sagging and wrinkles. Reduced elastin leads to signs of aging like sagging and loss of skin tone.

How Does Profhilo Stimulate Collagen and Elastin Production?

High-concentration hyaluronic acid (HA) binds to specialized receptors known as CD44 receptors on the surface of fibroblast cells found in the deeper layer of the skin. This engagement activates signaling pathways that enhance the synthesis of collagen and elastin.

https://londonskinclinic.london/pricing/

How Deep is Profhilo Injected?

Profhilo is injected into the fatty tissue just beneath the skin’s deep layer, known as the “superficial subcutaneous layer,” for three main reasons:

• There is enough tissue laxity for spreading the gel.
• It is close enough to fibroblasts within the deep layer of the skin to activate them.
• Injection in this subcutaneous layer minimizes the risk of injury to blood vessels, which can lead to skin necrosis.

Where Topographically on the Face is Profhilo Injected?

Profhilo is often delivered using the Bio Aesthetic Points (BAP) technique, targeting five specific injection points on each side of the face (total of 10 points). These anatomical points are chosen to minimize risks of bruising and maximize spread:

• Zygomatic protrusion (2cm from the outer corner of the eye).
• Nasal base (2cm from the nasal fold), in line with the pupil.
• Inferior margin of the tragus (1cm interior to the tragus).
• Labial commissure/chin (1/3 of the way down from the center of the lip with a marking of 1.5cm in either direction from the mid-line point).
• Jawline (1cm above the mandibular angle).

When Does Profhilo Start Working and How Long Does It Last?

Profhilo starts working within 24 hours and continues to deliver results for about six months.

Why are Two Sets of Injections Administered with a Four-Week Interval?

Profhilo is administered in two sessions, spaced four weeks apart, based on clinical evidence. The first session boosts collagen and elastin production, enhancing hydration and skin quality. The second session intensifies these effects, ensuring more profound and longer-lasting results. This timing aligns with the skin’s natural 28-day cycle, optimizing the bio-remodeling process.

What is the Evidence That Profhilo Works?

Clinical studies provide robust evidence that Profhilo is effective. Research has used precise tools to measure improvements in skin elasticity and hydration. Elasticity was measured using cutometry, which tests how well the skin bounces back after stretching. Studies show that skin becomes firmer and more elastic due to increased collagen and elastin production. Hydration was assessed using Corneometry, which analyzes moisture levels in the skin, demonstrating significant boosts in treated areas. Additionally, patients and doctors have reported visible and palpable improvements in skin texture and firmness.

FAQs

What is Profhilo?

Profhilo is an injectable gel with high-concentration hyaluronic acid used for skin rejuvenation, providing a firmer and more youthful appearance.

How does Profhilo work to enhance skin quality?

Profhilo works by immediately providing volume with hyaluronic acid, hydrating by binding to water molecules, and stimulating collagen and elastin production.

Where is Profhilo injected on the face?

It’s injected using the Bio Aesthetic Points technique, focusing on five specific points on each side of the face to minimize bruising risks.

How long do the effects of Profhilo last?

The effects typically last up to six months.

What evidence supports the efficacy of Profhilo?

Clinical studies using cutometry and Corneometry have shown significant improvements in elasticity and hydration, with visible enhancements noted by patients and doctors.